Phytochemical composition and cosmeceutical-related bioactivities of Canscora lucidissima (H. Lév. & Vaniot) Hand.-Mazz
學年 115
學期 1
出版（發表）日期 2026-10-05
作品名稱 Phytochemical composition and cosmeceutical-related bioactivities of Canscora lucidissima (H. Lév. & Vaniot) Hand.-Mazz
作品名稱（其他語言）
著者 Thi Thu le Vu; San-Lang Wang; Thanh Hue Pham; Dao Viet Hung; Van Quynh Giang; Thi Kim An Nguyen; Minh Quy Bui; Tu Quy Phan; Manh Dung Doan & Van Bon Nguyen
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates
摘要 Canscora lucidissima (H. Lév. & Vaniot) Hand.-Mazz. is a Vietnamese ethnomedicinal plant traditionally associated with anti-inflammatory use, yet its cosmeceutical potential remains poorly defined. This study provides an integrated evaluation of the phytochemical composition and cosmeceutical-related bioactivities of C. lucidissima solvent extracts, including antioxidant capacity, enzyme inhibitory, and antibacterial effects, together with in silico analyses of the identified phytochemicals covering molecular interactions, electronic features, and predicted ADME properties. Among the extracts, ethyl acetate showed the most consistent bioactivity profile, with the strongest tyrosinase inhibition (IC₅₀ = 195.24 µg/mL), α-amylase inhibition, DPPH and ABTS radical-scavenging activities, and antibacterial effects against Staphylococcus aureus and Escherichia coli. The ethanol extract exhibited the highest α-glucosidase inhibition (IC₅₀ = 96.46 µg/mL). Phytochemical screening and UHPLC-UV-based quantification revealed a solvent-dependent distribution of secondary metabolites. Exploratory PCA and Pearson correlation analyses indicated associations between the biological responses and phenolic/flavonoid profiles, particularly catechin, chlorogenic acid, rutin, quercitrin, and quercetin, but these associations should not be interpreted as evidence of causality. Molecular docking analysis identified rutin, quercitrin, and chlorogenic acid as potential ligands for tyrosinase (2Y9X), with rutin exhibiting the most favorable predicted binding affinity. Its HOMO–LUMO gap also suggested favorable electronic characteristics. ADME prediction indicated that quercetin and apigenin possessed the most balanced drug-likeness and permeability-related profiles, whereas highly polar glycosides were mainly limited by reduced passive absorption. Overall, this study provides an integrated preliminary assessment of the phytochemical profile, cosmeceutical-related bioactivities, and computational characteristics of C. lucidissima, highlighting its potential for further investigation as a multifunctional botanical ingredient.
關鍵字
語言 en
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 San-Lang, Wang
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/129976 )