Recent advances in the formulation and delivery applications of chitosan/fucoidan nanoparticles
學年 115
學期 1
出版（發表）日期 2026-09-01
作品名稱 Recent advances in the formulation and delivery applications of chitosan/fucoidan nanoparticles
作品名稱（其他語言）
著者 Trong-Ming Don; Kathleen L. Pagilagan; Kathlia D. Cruz; Po-Wei Tsai; Yi-Cheng Huang
單位
出版者
著錄名稱、卷期、頁數 International Journal of Biological Macromolecules 376, p. 153559
摘要 In the last few years, marine polysaccharides have gained attention for their biological activities that are beneficial for several biomedical applications. Among them, chitosan and fucoidan are known for their biocompatibility, bioactivities, and biodegradability, making them desirable for drug delivery. Under suitable environmental conditions, chitosan can carry cationic charges and has a strong electrostatic interaction with the anionic fucoidan, leading to ionic crosslinking and resulting in a polyelectrolyte complex. Therefore, when used in combination as nanoparticles, various enhanced bioactivities such as antioxidant, anti-inflammatory, and antibacterial effects in drug delivery, regenerative medicine, and cancer treatment have been reported with little toxicity. With further chemical and physical modifications, it can encompass several additional properties suitable for its applications. Particularly, chitosan/fucoidan nanoparticles have been used for creating a drug or bioactive compound delivery system that results in improved drug solubility, stability, and bioavailability. This review aims to present the recent advancements and applications of chitosan/fucoidan formulations and nanoparticles and their benefits in biomedical applications, particularly in drug delivery applications.
關鍵字 Chitosan; Fucoidan; Drug delivery
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/129799 )