Preparation of polypyrrole-ulvan nanoparticles and bioactive properties of multifunctional polypyrrole-ulvan/chitosan dressings for enhanced wound healing
學年 114
學期 2
出版（發表）日期 2026-06-01
作品名稱 Preparation of polypyrrole-ulvan nanoparticles and bioactive properties of multifunctional polypyrrole-ulvan/chitosan dressings for enhanced wound healing
作品名稱（其他語言）
著者 Trong-Ming Don; Hung-Chih Tai; Ying-Chun Chen; Yi-Cheng Huang
單位
出版者
著錄名稱、卷期、頁數 Carbohydrate Polymers 381, p. 125196
摘要 Both ulvan (U) and Chitosan (C) have biocompatibility, bioactivities and wound healing properties. On the other hand, polypyrrole (PPy) is a synthetic conductive polymer capable of modulating the wound microenvironment and promoting tissue regeneration. In this study, a multifunctional wound dressing was developed, based on chitosan matrix with evenly dispersed conductive PPy-U nanoparticles (237–323 nm). PPy was synthesized in-situ within ulvan solution, producing PPy-U nanoparticles that could stably disperse in water, overcoming the poor solubility of PPy. The resulting PPy-U/C films exhibited tunable conductivity (10−2–10−3 S·m−1), and increased flexibility with the addition of glycerol (G). Moreover, ulvan enhanced swelling ratio (255–518%) and water vapor transmission rate (1400–1640 g·m−2·day−1), whereas PPy imparted conductivity and intrinsic antibacterial activity against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The complex films protected HaCaT cells from H₂O₂-induced oxidative stress and significantly enhanced the proliferation of NIH 3 T3 fibroblasts under electrical stimulation. In vivo full-thickness wound-healing studies demonstrated that PPy-U/C—particularly PPy0.1-U1/C3-G—accelerated re-epithelialization and achieved complete wound closure within 14 days. These results demonstrate that the PPy-U/C film is a carbohydrate-based, electroactive, and antibacterial wound dressing with strong potential to enhance cellular activity and accelerate wound healing.
關鍵字
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/129796 )