A highly sensitive WS2 quantum dots nanocoated surface plasmonic resonance based side polished fiber sensor for detection of Parkinson's disease
學年 114
學期 2
出版（發表）日期 2026-04-01
作品名稱 A highly sensitive WS2 quantum dots nanocoated surface plasmonic resonance based side polished fiber sensor for detection of Parkinson's disease
作品名稱（其他語言）
著者 J. Mohanraj; M. Valliammai; Lung-Jieh Yang; Gulothungan G; N. Ayyanar; Jeyanthi P
單位
出版者
著錄名稱、卷期、頁數 IEEE Sensors Letters 10(4), p.1500904
摘要 In this letter, we propose a highly sensitive evanescent field-based side polished fiber (SPF) biosensor nanocoated with tungsten disulfide (WS2) quantum dots (QDs) for the label-free detection of Parkinson's disease (PD). Alpha-synuclein (α-syn) is identified as a key biomarker for the early and rapid diagnosis of PD. The sensing mechanism relies on surface plasmon resonance (SPR)-based interaction between the evanescent field in the anti-α-syn antibodies immobilized on the (WS2) QDs and SPF region. The proposed biosensor demonstrates a sensitivity of 85% with a limit of detection around 0.517 fg/mL. A maximum SPR wavelength shift of 97.62 nm was observed at an α-syn concentration of 105 fg/mL. Further, the proposed biosensor exhibits an excellent selectivity toward α-syn compared to potential interfering proteins, such as amyloid-beta (Aβ42) and bovine serum albumin. Thus, the proposed WS2 QDs nano-coated SPF biosensor is a promising platform for point-of-care diagnostics and preclinical assessment of PD.
關鍵字
語言 en_US
ISSN 2475-1472
期刊性質 國外
收錄於 SCI Scopus
產學合作
通訊作者 J. Mohanraj
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/129650 )

SDGS 潔淨水與衛生,產業創新與基礎設施,夥伴關係