Divergent Synthesis of Heterotricyclic Compounds from γ-Alkynyl-1,3-diketones via Base-Mediated Tandem Annulations
學年 113
學期 2
出版（發表）日期 2025-07-04
作品名稱 Divergent Synthesis of Heterotricyclic Compounds from γ-Alkynyl-1,3-diketones via Base-Mediated Tandem Annulations
作品名稱（其他語言）
著者 Ming-Yang Chang; Yu-Guang Lin; Fang-Yi Jen; Yi-En Liang; Hsi Ho; Wen-Tai Li
單位
出版者
著錄名稱、卷期、頁數 Organic Letters 27(26), p.7182-7187
摘要 This paper presents a novel base-mediated strategy for the divergent synthesis of oxygen- and nitrogen-containing heterotricyclic compounds, furo­[3,2-c]­chromene and furo­[3,2-c]­quinolone, from γ-alkynyl 1,3-diketones without the use of transition metals. These one-pot tandem reaction methodologies demonstrate remarkable versatility, enabling base-mediated O-attack via 5-exo-dig or C-attack intramolecular cyclization onto the alkyne, leading to the formation of furo­[3,2-c]­chromene or xanthone products. Additionally, sequential reactions involving regioselective condensation followed by tandem annulation afford furo­[3,2-c]­quinolone. These approaches leverage precisely controlled reaction conditions to direct selective annulation pathways, facilitating the construction of diverse heterocyclic frameworks with significant pharmaceutical potential.
關鍵字
語言 en
ISSN 1523-7052; 1523-7060
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/129592 )