Chitosan/carboxymethyl cellulose nanocomposites prepared via electrolyte gelation–spray drying for controlled ampicillin delivery and enhanced antibacterial activity
學年 114
學期 1
出版（發表）日期 2026-01-24
作品名稱 Chitosan/carboxymethyl cellulose nanocomposites prepared via electrolyte gelation–spray drying for controlled ampicillin delivery and enhanced antibacterial activity
作品名稱（其他語言）
著者 Nguyen AD, Nguyen VN, Tran VH, Ding HH, Nguyen DS, Nguyen TH, Nguyen VB, Wang SL
單位
出版者
著錄名稱、卷期、頁數 Polymers, 18(03): 319
摘要 This study reports the fabrication of chitosan/carboxymethyl cellulose (C/M) nanocomposites by electrolyte gelation-spray drying and the evaluation of their antibacterial performance as carriers for the antibiotic ampicillin. Chitosan (C), a cationic biopolymer derived from chitin, was combined with the anionic polysaccharide carboxymethyl cellulose (M) at different mass ratios to form stable nanocomposites via electrostatic interactions and then collected by a spraying dryer. The resulting particles exhibited mean diameters ranging from 800 to 1500 nm and zeta potentials varying from +90 to −40 mV, depending on the C:M ratio. The optimal formulation (C:M = 2:1 ratio) achieved a high recovery yield (71.1%) and ampicillin encapsulation efficiency EE (82.4%). Fourier transform infrared spectroscopy (FTIR) confirmed the presence of hydrogen bonding and ionic interactions among C:M, and ampicillin within the nanocomposite matrix. The nano-microcomposites demonstrated controlled ampicillin release and pronounced antibacterial activity against Staphylococcus aureus, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 3.2 µg/mL and 5.3 µg/mL, respectively, which were lower than those of free ampicillin. These results indicate that the chitosan/carboxymethyl cellulose nano-microcomposites are promising, eco-friendly carriers for antibiotic delivery and antibacterial applications.
關鍵字 chitosan; carboxymethyl cellulose; nanocomposite; ampicillin; spray drying; antibacterial activity
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 CHE
公開徵稿
出版型式 ,電子版