Chitosan/carboxymethyl cellulose nanocomposites prepared via electrolyte gelation–spray drying for controlled ampicillin delivery and enhanced antibacterial activity
學年 114
學期 1
出版（發表）日期 2026-01-24
作品名稱 Chitosan/carboxymethyl cellulose nanocomposites prepared via electrolyte gelation–spray drying for controlled ampicillin delivery and enhanced antibacterial activity
作品名稱（其他語言）
著者 Anh Dzung Nguyen; Vinh Nghi Nguyen; Vu Hoa Tran; Huu Hung Dinh; Dinh Sy Nguyen; Thi Huyen Nguyen; Van Bon Nguyen; San Lang Wang
單位
出版者
著錄名稱、卷期、頁數 Polymers 18(3), p. 319
摘要 This study reports the fabrication of chitosan/carboxymethyl cellulose (C/M) nanocomposites by electrolyte gelation-spray drying and the evaluation of their antibacterial performance as carriers for the antibiotic ampicillin. Chitosan (C), a cationic biopolymer derived from chitin, was combined with the anionic polysaccharide carboxymethyl cellulose (M) at different mass ratios to form stable nanocomposites via electrostatic interactions and then collected by a spraying dryer. The resulting particles exhibited mean diameters ranging from 800 to 1500 nm and zeta potentials varying from +90 to −40 mV, depending on the C:M ratio. The optimal formulation (C:M = 2:1 ratio) achieved a high recovery yield (71.1%) and ampicillin encapsulation efficiency EE (82.4%). Fourier transform infrared spectroscopy (FTIR) confirmed the presence of hydrogen bonding and ionic interactions among C:M, and ampicillin within the nanocomposite matrix. The nano-microcomposites demonstrated controlled ampicillin release and pronounced antibacterial activity against Staphylococcus aureus, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 3.2 µg/mL and 5.3 µg/mL, respectively, which were lower than those of free ampicillin. These results indicate that the chitosan/carboxymethyl cellulose nano-microcomposites are promising, eco-friendly carriers for antibiotic delivery and antibacterial applications.
關鍵字 chitosan; carboxymethyl cellulose; nanocomposite; ampicillin; spray drying; antibacterial activity
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 CHE
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/128550 )