The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database
學年 109
學期 1
出版（發表）日期 2020-11-24
作品名稱 The metabolic syndrome is associated with the risk of urothelial carcinoma from a health examination database
作品名稱（其他語言）
著者 Hsiang-Ying Lee; Jia-Hong Tang; Yen-Hsu Chen; Wen-Jeng Wu; Yung-Shun Juan; Wei-Ming Li; Ta-Chien Chan
單位
出版者
著錄名稱、卷期、頁數 International Journal of Clinical Oncology 26, p. 569–577
摘要 Purpose The metabolic syndrome was associated with bladder cancer in the previous studies. However, there have no large-scale cohort studies to elucidate the relationship between metabolic syndromes and urothelial carcinoma including urinary bladder urothelial carcinoma (UBUC) and upper tract urothelial carcinoma (UTUC). Methods We analyze a population-based cohort study by using physical examination data and diagnosis of UC from the Taiwan Cancer Registry Database. Differences in demographic and clinical characteristics among UTUC and non-UTUC groups, UBUC and non-UBUC groups were compared. Odds ratios (ORs) for determining risk factors were estimated through the multiple logistic regression model. Results A total of 557,063 records for 211,319 participants which consisted of 31 UTUC and 309 UBUC met the eligibility criteria in this study. Our results showed that female are more likely to develop UTUC than male. As opposed to UTUC, male are more likely to develop UBUC than female. It also showed that participants smoked or chewed betel quid daily are more likely to develop UBUC. Age and estimated glomerular filtration rate (eGFR) are significantly increased the risk of developing UTUC. The association between the eGFR and risk of UTUC is stronger (P < 0.001) for eGFR < 45 (vs. eGFR ≥ 75, OR = 6.795; 95% CI 2.901–15.917). Metabolic syndrome is related to higher risk of UBUC incidence [OR was 1.373 (95% CI 1.104–1.707)]. Conclusions There was a significant relationship between the incidence of UBUC and metabolic syndrome. Renal function impairment presents higher risk in both UBUC and UTUC development.
關鍵字
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI Scopus
產學合作
通訊作者 Ta-Chien Chan
審稿制度 是
國別 DEU
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/128432 )

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