High-Level Scale Bioproduction of Prodigiosin Using a Novel Designed Culture Medium Completely Based on Organic By-Products and its Potential Anti-Alzheimer Effect: An Experimental and Virtual Study
學年 114
學期 1
出版（發表）日期 2026-01-01
作品名稱 High-Level Scale Bioproduction of Prodigiosin Using a Novel Designed Culture Medium Completely Based on Organic By-Products and its Potential Anti-Alzheimer Effect: An Experimental and Virtual Study
作品名稱（其他語言）
著者 Thi Hanh Nguyen; Chi-Hao Wang; San-Lang Wang; Anh Dzung Nguyen; Tu Quy Phan; Van Bon Nguyen
單位
出版者
著錄名稱、卷期、頁數 Current Microbiology 83(1), p.73
摘要 The red microbial pigment - prodigiosin has attracted much attention in research due to its multiple bioactivities, which can be applied in various fields. Production prodigiosin with an eco-friendly strategy is currently an interesting and prioritized research topic. This study introduces an innovative production approach utilizing a novel, eco-friendly culture medium system that completely replaces expensive commercial nutrients with a combination of low-cost organic byproducts (shrimp shell powder and groundnut oil cake). This new approach yielded a remarkably high prodigiosin concentration (7520 mg/L) in an exceptionally short cultivation time (8 h) during large-scale fermentation. Beyond sustainable production, this research identified a novel therapeutic potential for prodigiosin in managing Alzheimer's disease via its ability to block cholinesterase enzymes, which are key targets in Alzheimer's therapy. Besides the experimental approach, computational simulations were used to predict the drug-likeness, pharmacokinetics, and safety profiles of prodigiosin in two forms (neutral and cationic). Notably, molecular docking and DFT analysis revealed effective interactions of prodigiosin with cholinesterase enzymes, with the cationic form showing a more promising capacity for protein target interaction. This study provided scientific insights into the eco-friendly cultural medium for prodigiosin production, its anti-cholinesterase activity, and potential properties through virtual simulations.
關鍵字
語言 zh_TW
ISSN
期刊性質 國內
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 TWN
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/128334 )