A simple and versatile degradable polymeric capsule for sustained delivery of bioactive molecules
學年 114
學期 1
出版（發表）日期 2025-11-26
作品名稱 A simple and versatile degradable polymeric capsule for sustained delivery of bioactive molecules
作品名稱（其他語言）
著者 Tzu-Wei Huang; Chih-Yang Lai; Po-Ju Lai; Rifky Rahardian Setiawan; Chao-Tsai Huang; Yi-Hua Kuo; Shih-Jung Liu
單位
出版者
著錄名稱、卷期、頁數 International Polymer Processing
摘要 Traditional fabrication methods for delivery vehicles often rely on thermal or solvent processing, which can pose challenges for heat- and solvent-sensitive bioactive molecules, such as proteins and peptides. These molecules may denature or lose their biological activity, ultimately reducing their therapeutic efficacy. This study proposed a simple and versatile biodegradable perforated capsule for sustained delivery of bioactive molecules. Poly (lactic-coglycolic acid) (PLGA) capsules with side perforations were fabricated using a compressionmolding method. Teicoplanin, mixedwith either phosphate-buffered solution, Pluronic F-127 hydrogel, or hyaluronic acid, was then filled into the core of the capsules. The in vitro release rates of teicoplanin were characterized over a 30-day period using an elution method and a high performance liquid chromatography (HPLC) assay. The experimental results demonstrated that the biodegradable perforated capsules released high concentrations of teicoplanin, exceeding the minimum inhibitory concentration (MIC), in vitro for 30 days. Furthermore, the high viscosity of the Pluronic F-127 hydrogel and hyaluronic acid prolonged the antibiotic’s release period. This novel capsule design holds significant promise for delivering active biomolecules, including drugs, proteins, and peptides, for long-term therapeutic applications.
關鍵字 perforated capsule;polylactide-polyglycolide;teicoplanin;release profiles
語言 en
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Shih-Jung Liu
審稿制度 否
國別 DEU
公開徵稿
出版型式 ,電子版,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/128327 )