Design and synthesis of unsymmetric benzils, quinoxalines, and evaluations of their anticancer activities against human non-small lung cancer cells
學年 113
學期 2
出版（發表）日期 2025-03-15
作品名稱 Design and synthesis of unsymmetric benzils, quinoxalines, and evaluations of their anticancer activities against human non-small lung cancer cells
作品名稱（其他語言）
著者 Ping-Chih Hsu; Yu-Hsin Hsu; Chuan-Hsin Chang; Tzenge-Lien Shih
單位
出版者
著錄名稱、卷期、頁數 ChemMedChem 20(6) ,p. e202400847
摘要 Quinoxaline and its derivatives exhibit a broad spectrum of biological activity, making them valuable for various therapeutic applications. However, most quinoxalines are synthetically produced due to their scarcity in nature. In this article, a series of unsymmetric benzils were synthesized and subsequently condensed with 1,2-diaminobenzene to produce unsymmetric quinoxalines. The novel synthetic benzils and quinoxalines were evaluated for their anticancer activities against human non-small-cell lung cancer (NSCLC) cells harboring different gene mutations, to explore their potential as anticancer agents. Among these synthesized molecules, compound 5 g demonstrated inhibitory effects comparable to those of cisplatin.
關鍵字 Anticancer activities;Sonogarshira reaction;Unsymmetric benzil;Unsymmetric quinoxaline
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 施增廉
審稿制度 是
國別 GBR
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/128270 )