The angiogenesis-modulating effects of coumarin-derivatives
學年 112
學期 2
出版（發表）日期 2024-02-19
作品名稱 The angiogenesis-modulating effects of coumarin-derivatives
作品名稱（其他語言）
著者 Han-Ting Huang; Ching-Yuan Huang; Chih-Jou Lee; Bo-Jie Sun; Zong-Wei Jhang; Chi-Chung Wen; Yun-Hsin Wang; Tao-Sheng Li; Ching-Yuh Chern; Yau-Hung Chen
單位
出版者
著錄名稱、卷期、頁數 Comparative Biochemistry and Physiology C: Toxicology and Pharmacology 278, 109862
摘要 Coumarin is a natural compound that is rich in plants. Coumarin and its derivates were reported to have many biological activities, such as anti-bacterial, anti-tumor, and anti-coagulation. In this study, we examined the angiogenic modulating activities of six previously synthesized coumarin derivatives (Compound #1-#6) in zebrafish embryos and further confirmed them in a chick model. According to the survival rate in a zebrafish model, Compound #1 (100 %), #2 (82.5–100 %), and #4 (100 %) showed much less toxicity than Compound #3 (19.2–100 %), #5 (0–100 %), and #6 (0–100 %). Using a green blood vessel fluorescent transgenic fish Tg(fli1:egfp) to record the angiogenesis-modulating effects of Compound #1, #2, and #4, we found that Compound #2 had the highest effects in interfering intersegmental vessel growth, subintestinal vein growth, and caudal vein plexus remodeling. Chick chorioallantoic membrane (CAM) assay also showed that Compound #2 exposure led to a reduction of blood vessel growth. Real-time PCR experiments revealed that Compound #2 significantly changed the expression of vascular growth-related genes flt1, cdh5, and nrp1a in zebrafish. Based on our data from zebrafish and chick models, a new coumarin-derivative (Compound #2) possesses anti-angiogenic activity with low toxicity, but further investigation in mammal models is asked to confirm our findings.
關鍵字
語言 en_US
ISSN 1878-1659; 1532-0456
期刊性質 國外
收錄於 SCI SSCI ESCI
產學合作
通訊作者
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/127551 )