Effects of intubation and hypoxemia on intraventricular hemorrhage in preterm infants during the first week: An observational study
學年 113
學期 1
出版（發表）日期 2024-10-04
作品名稱 Effects of intubation and hypoxemia on intraventricular hemorrhage in preterm infants during the first week: An observational study
作品名稱（其他語言）
著者 Chang, Yue-cune
單位
出版者
著錄名稱、卷期、頁數 Heart & Lung 69,　p.78-86
摘要 Background: Preterm infants with intraventricular hemorrhage (IVH) are at a risk of developing neurodevelopmental disabilities. Few studies have examined the effects of oxygen saturation (SpO2) changes and intubation procedures on the risk of IVH. Objectives: We examined the effects of intubation and the rates of three thresholds of hypoxemia on the occurrence of IVH in preterm infants during their first week in the neonatal intensive care unit (NICU). Methods: In this prospective observational cohort study, preterm infants with a gestational age (GA) of <37 weeks were included from two Level III NICUs in Taiwan. Continuous electrocardiography was used to monitor SpO2 changes, and cranial ultrasonography was used to monitor IVH. Thresholds of hypoxemia (SpO2 levels of <80 %, <85 %, and <90 %) were screened by digitally sampling data at 10-s intervals. Generalized estimating equations were used with logistic regression to analyze the effects of intubation and the rates of the three thresholds of hypoxemia on the risk of IVH during the first week after birth. Results: In all preterm infants (N = 73), the mean GA was 31.55 weeks, and the mean birth weight was 1508.86 g. Intubation within 3 days of birth, duration of mechanical ventilation and oxygen use, hypoxemia rate, and maternal use of magnesium sulfate before and during delivery were significantly associated with IVH. A multivariate analysis revealed that intubation was a key factor associated with the occurrence of IVH across different thresholds of hypoxemia (p = 0.004). Conclusions: Although the rate of hypoxemia, duration of mechanical ventilation and oxygen use, and maternal use of magnesium sulfate were significantly associated with IVH, intubation within 3 days of birth was the key factor responsible for increased IVH risk.
關鍵字 Hypoxemia;Intensive care;Intraventricular hemorrhage;Intubation;Preterm infants
語言 en_US
ISSN 1527-3288
期刊性質 國外
收錄於 SCI Scopus
產學合作
通訊作者 Jen-Jiuan Liaw
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/126606 )