Flavonol-ruthenium complexes as antioxidant and anticancer agents
學年 113
學期 1
出版（發表）日期 2024-09-11
作品名稱 Flavonol-ruthenium complexes as antioxidant and anticancer agents
作品名稱（其他語言）
著者 Wu, Ting-wei; Tang, Mei-hsin; Hsu, Pei-hsuan; Wu, Hsin-ying; Shih, Tzenge-lien
單位
出版者
著錄名稱、卷期、頁數 ChemMedChem 19(24),　e202400313
摘要 Flavonol-metal complexes can enhance the biological activity of flavonols. Inspired by the potential of ruthenium-based drugs in pharmaceutical applications, seven flavonol-Ru (II) complexes were synthesized to evaluate their biological activities. Among these compounds, compounds 8, 11, and 12 showed potent antioxidant activities. Compound 12 exhibited superior anti-inflammatory activity to natural quercetin, which served as a positive control. This study is the first to report the free radical scavenging abilities and antioxidant activity of flavonol-Ru (II) complexes. Furthermore, compound 12 demonstrated comparable efficacy to 5-FU against human non-small-cell lung cancer cells (A549). These results strongly support the potential of flavonol-Ru (II) agents.
關鍵字 Anti-inflammatory;Anticancer;Antioxidant;Flavonol;Flavonol-ruthenium complexes
語言 en_US
ISSN 1860-7187
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/126886 )