Preparation and characterization of chitosan/starch nanocomposite loaded ampicillin to enhance anti-bacterial activity against Escherichia coli
學年 113
學期 1
出版（發表）日期 2024-09-15
作品名稱 Preparation and characterization of chitosan/starch nanocomposite loaded ampicillin to enhance anti-bacterial activity against Escherichia coli
作品名稱（其他語言）
著者 Vinh Nghi Nguyen; San-Lang Wang; Thi Huyen Nguyen; Van Bon Nguyen; Manh Dung Doan; Anh Dzung Nguyen
單位
出版者
著錄名稱、卷期、頁數 Polymers, 16(18): 2647
摘要 Chitosan/starch nanocomposites loaded with ampicillin were prepared using the spray-drying method by mixing various ratios of chitosan and starch. The morphology of chitosan/starch nanoparticles was studied using a scanning electron microscope (SEM), and the zeta potential value and size distribution were determined by a Nanoparticle Analyzer. The results show that the chitosan/starch nanocomposites have a spherical shape, smooth surface, and stable structure. Nanoparticle size distribution ranged from 100 to 600 nm, and the average particle size ranged from 300 to 400 nm, depending on the ratio between chitosan and starch. The higher the ratio of starch in the copolymer, the smaller the particle size. Zeta potential values of the nanocomposite were very high, ranging from +54.4 mV to +80.3 mV, and decreased from 63.2 down to +37.3 when loading with ampicillin. The chitosan/starch nanocomposites were also characterized by FT-IR to determine the content of polymers and ampicillin in the nanocomposites. The release kinetics of ampicillin from the nanocomposites were determined in vitro using an HPLC profile for 24 h. The loading efficiency (LE) of ampicillin into chitosan/starch nanoparticles ranged from 75.3 to 77.3%. Ampicillin-loaded chitosan/starch nanocomposites were investigated for their antibacterial activity against antibiotic-resistant Escherichia coli in vitro. The results demonstrate that the antibacterial effectiveness of nanochitosan/starch loading with ampicillin against E.coli was 95.41%, higher than the 91.40% effectiveness of ampicillin at the same concentration of 5.0 µg/mL after 24 h of treatment. These results suggest that chitosan/starch nanocomposites are potential nanomaterials for antibiotic drug delivery in the pharmaceutical field.
關鍵字 chitosan; starch; nanocomposites; ampicillin; E. coli; drug delivery
語言 zh_TW
ISSN 2073-4360
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 San-Lang, Wang
審稿制度 是
國別 CHE
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/126221 )

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