Synthesis of quinoxalines and assessment of their inhibitory effects against human non-small-cell lung cancer cells
學年 113
學期 1
出版（發表）日期 2024-09-09
作品名稱 Synthesis of quinoxalines and assessment of their inhibitory effects against human non-small-cell lung cancer cells
作品名稱（其他語言）
著者 Jia-Hua Liang,a Shu-Tse Cho,b Tzenge-Lien Shih*b and Jih-Jung Chen
單位
出版者
著錄名稱、卷期、頁數 RSC Adv., 14, 28659-28668
摘要 Twenty-six quinoxalin derivatives were synthesized to assess their biological activities against human non-small-cell lung cancer cells (A549 cells). Compound 4b (IC50 = 11.98 ± 2.59 μM) and compound 4m (IC50 = 9.32 ± 1.56 μM) possess anticancer activity comparable to 5-fluorouracil (clinical anticancer drug) (IC50 = 4.89 ± 0.20 μM). Western blot tests further confirmed that compound 4m effectively induced apoptosis of A549 cells through mitochondrial- and caspase-3-dependent pathways. The introduction of bromo groups instead of nitro groups into the quinoxaline skeleton has been shown to provide better inhibition against lung cancer cells in this article. This modification in the molecular structure could enhance the biological activity and effectiveness of quinoxaline derivatives in the design and synthesis of anticancer drugs, making bromo-substituted quinoxalines a promising avenue for further research and development in anticancer therapeutics.
關鍵字
語言 en
ISSN 2046-2069
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 DEU
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/126209 )