Synthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents
學年 112
學期 2
出版（發表）日期 2024-04-28
作品名稱 Synthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents
作品名稱（其他語言）
著者 Yu-Hui Hsieh; Pei-Hsuan Hsu; Anren Hu; Yang-Je Cheng; Tzenge-Lien Shih; Jih-Jung Chen
單位
出版者
著錄名稱、卷期、頁數 Molecules 29(9), 2041
摘要 A series of flavanols were synthesized to assess their biological activity against human non-small cell lung cancer cells (A549). Among the sixteen synthesized compounds, it was observed that compounds 6k (3.14 ± 0.29 µM) and 6l (0.46 ± 0.02 µM) exhibited higher potency compared to 5-fluorouracil (5-Fu, 4.98 ± 0.41 µM), a clinical anticancer drug which was used as a positive control. Moreover, compound 6l (4’-bromoflavonol) markedly induced apoptosis of A549 cells through the mitochondrial- and caspase-3-dependent pathways. Consequently, compound 6l might be developed as a candidate for treating or preventing lung cancer.
關鍵字 anticancer agent; human non-small cell lung cancer cell; flavonol
語言 en
ISSN 1420-3049
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 CHE
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/126208 )