Injectable ChitHCl-MgSO4-DDA hydrogel as a bone void filler to improve cell migration and osteogenesis for bone regeneration
學年 112
學期 2
出版（發表）日期 2024-05-18
作品名稱 Injectable ChitHCl-MgSO4-DDA hydrogel as a bone void filler to improve cell migration and osteogenesis for bone regeneration
作品名稱（其他語言）
著者 Wang, Yu-tzu
單位
出版者
著錄名稱、卷期、頁數 International Journal of Biological Macromolecules 270(2),　132409
摘要 Suture pull-through is a clinical problem in meniscus repair surgery due to the sharp leading edge of sutures. Several tissue adhesives have been developed as an alternative to traditional suturing; however, there is still no suitable tissue adhesive specific for meniscus repair treatment due to unsatisfactory biosafety, biodegradable, sterilizable, and tissue-bonding characteristics. In this study, we used a tissue adhesive composed of chitosan hydrochloride reacted with oxidative periodate-oxidized dextran (ChitHCl-DDA) combined with a chitosan-based hydrogel and oxidative dextran to attach to the meniscus. We conducted viscoelastic tests, viscosity tests, lap shear stress tests, Fourier transform infrared (FTIR) spectroscopy, swelling ratio tests, and degradation behavior tests to characterize these materials. An MTT assay, alcian blue staining, migration assay, cell behavior observations, and protein expression tests were used to understand cell viability and responses. Moreover, ex vivo and in vivo tests were used to analyze tissue regeneration and biocompatibility of the ChitHCl-DDA tissue adhesive. Our results revealed that the ChitHCl-DDA tissue adhesive provided excellent tissue adhesive strength, cell viability, and cell responses. This tissue adhesive has great potential for torn meniscus tissue repair and regeneration.
關鍵字
語言 en_US
ISSN 1879-0003
期刊性質 國外
收錄於 SCI SSCI ESCI
產學合作
通訊作者
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/125877 )