Assessment of the chemical profile and potential medical effect of flavonoids-rich extract of Eclipta prostrata L. collected in the Central Highland of Vietnam
學年 112
學期 1
出版（發表）日期 2023-10-16
作品名稱 Assessment of the chemical profile and potential medical effect of flavonoids-rich extract of Eclipta prostrata L. collected in the Central Highland of Vietnam
作品名稱（其他語言）
著者 Phan TKP, Wang SL, Nguyen QV, Phan TQ, Nguyen TT, Toan TTT, Nguyen AD, Nguyen VB, Doan MD
單位
出版者
著錄名稱、卷期、頁數 Pharmaceuticals 16(10), 1476
摘要 Eclipta prostrata L. (EPL), a medicinal plant, is widely utilized in the central highlands of Vietnam. This study aims to assess the chemical profile and potential medical effects of an EPL extract rich in flavonoids. A total of 36 secondary metabolites were identified from the EPL extract through GC-MS and UHPLC-UV analysis. Among them, 15 volatile compounds and several phenolic and flavonoid chemicals, including salicylic acid, epicatechin gallate, isovitexin, and apigetrin, were reported in EPL extract for the first time. This herbal extract demonstrated moderate inhibition against α-amylase and α-glucosidase, and high anti-oxidant and anti-acetylcholinesterase activities (IC50 = 76.8 ± 0.8 μg/mL). These promising attributes can be likely attributed to the high levels of major compounds, including wedelolactone (1), chlorogenic acid (3), epicatechin gallate (6), salicylic acid (8), isovitexin (9), apigetrin (11), and myricetin (12). These findings align with the traditional use of EPL for enhancing memory and cognitive function, as well as its potential benefits in diabetes management. The results of the molecular docking study reveal that the major identified compounds (1, 6, 9, and 11) showed a more effective acetylcholinesterase inhibitory effect than berberine chloride, with good binding energy (DS values, −12.3 to −14.3 kcal/mol) and acceptable values of RMSD (1.02–1.67 Å). Additionally, almost all the identified major compounds exhibited good ADMET properties within the required limits.
關鍵字
語言 en
ISSN 1424-8247
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 CHE
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/125499 )

SDGS 消除貧窮,消除飢餓,良好健康和福祉