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學年
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112 |
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學期
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2 |
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出版（發表）日期
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2024-04-28 |
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作品名稱
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Synthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents |
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作品名稱（其他語言）
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著者
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Hsu, Pei-hsuan; Cheng,Yang-je; Shih, Tzenge-lien |
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單位
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出版者
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著錄名稱、卷期、頁數
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Molecules 29(9), 2041 |
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摘要
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A series of flavanols were synthesized to assess their biological activity against human non-small cell lung cancer cells (A549). Among the sixteen synthesized compounds, it was observed that compounds 6k (3.14 ± 0.29 µM) and 6l (0.46 ± 0.02 µM) exhibited higher potency compared to 5-fluorouracil (5-Fu, 4.98 ± 0.41 µM), a clinical anticancer drug which was used as a positive control. Moreover, compound 6l (4’-bromoflavonol) markedly induced apoptosis of A549 cells through the mitochondrial- and caspase-3-dependent pathways. Consequently, compound 6l might be developed as a candidate for treating or preventing lung cancer. |
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關鍵字
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anticancer agent;human non-small cell lung cancer cell;flavonol |
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語言
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en_US |
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ISSN
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1420-3049 |
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期刊性質
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國外 |
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收錄於
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SCI
Scopus
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產學合作
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通訊作者
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審稿制度
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否 |
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國別
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SWE |
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公開徵稿
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出版型式
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,電子版 |
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