Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging
學年 112
學期 1
出版(發表)日期 2023-10-13
作品名稱 Low-Toxicity Antibacterial Carbon Nanodots for Wound Dressings and Food Packaging
著者 Huang, Chia-chi
著錄名稱、卷期、頁數 ACS Appl. Nano Mater. 2023(6), 19200-19209
摘要 Carbon nanodots (CDs) are known to inhibit the growth of bacteria, and a developing trend is observed in the literature that attributes such activities specifically to photoactivation, N-doping, and/or surface charge. In this study, we demonstrate that CDs can inhibit bacteria growth as well without these predispositions. Using the minimum inhibitory concentration and minimum bactericidal concentration protocols, we study, without irradiation, the inhibitory activities of CDs that are low in N-content and surface charge, against Escherichia coli O157:H7, Salmonella enterica ser. Typhimurium, and Staphylococcus aureus. The CDs are further tested in a zebrafish model for acute toxicity. These CDs exhibit antibacterial activities comparable to those of previously reported CDs with IC50s of 0.66, 0.75, and 1.00 mg/mL for the three bacteria, respectively. They are also shown to have manageable acute toxicity for safe applications in areas such as antibacterial wound dressing and food packaging. These results indicate that our knowledge base of the required characteristics for CDs to be antibacterial is incomprehensive despite the burgeoning of studies in this area, and the biological pathways leading to such activities are much more diverse than the current literature has suggested.
關鍵字 carbon nanodots (CDs),bactericidal,bacteriostatic,Escherichia coli O157:H7,Salmonella enterica,Staphylococcus aureus
語言 en_US
期刊性質 國內
收錄於 SCI Scopus
通訊作者 Chia-Chi Huang
國別 TWN
出版型式 ,電子版

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/124696 )