Phytochemical profiles and novel bio-functions of Dillenia ovata Wall. ex Hook.f. et Thomson: A Vietnamese indigenous medicinal plant.
學年 112
學期 1
出版（發表）日期 2023-09-27
作品名稱 Phytochemical profiles and novel bio-functions of Dillenia ovata Wall. ex Hook.f. et Thomson: A Vietnamese indigenous medicinal plant.
作品名稱（其他語言）
著者 Doan MD, Wang SL, Nguyen VB, Phan TKP, Phan TQ, Nguyen TT, Nguyen TH, Nguyen VQ, Nguyen AD
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates, 49(08):1-27
摘要 Dillenia ovata Wall. ex Hook. f. et Thomson (DOWHT)- an indigenous medicinal plant collected in the Central Highland of Vietnam has been utilized by medical folks for ages. However, almost related scientific evidence still has not been clarified. This study aimed to report the phytochemical profiles and novel potent bio-functions of DOWHT. The testing bioactivities of different parts used of DOWHT indicated this herbal demonstrated moderated inhibition against α-amylase and α-glucosidase while it showed potent antioxidant and anti-acetylcholinesterase (AChE). Of these, the inhibition against the key enzymes targeting anti-diabetes and Alzheimer's disease was notably reported for the first time. The phytochemical profiles of all the parts used of DOWHT were investigated via GCMS and UHPLC analysis. Totally, 46 compounds, including 30 volatiles (compounds 1-30) and 16 phenolics (compounds 31-46) were newly identified from DOWHT extracts. In this work, various volatiles and phenolics were newly found in this herbal species. In the docking study, some major phenolics including Epigallocatechin gallate (34), Epicatechin gallate (36), Vitexin (37), and Apigetrin (41) possess DS values (-12.5 to -13.3 kcal/mol) better than Berberine chloride (-12.1 kcal/mol). Moreover, almost tested metabolites comply with the drug-likeness properties of Lipkin's rules prediction and non-toxicity via the ADMET test. The results suggest the herb DOWHT may be a potential source for drug discovery and these in silico results may be good reference information for further in vitro and in vivo experiments.
關鍵字 Dillenia ovata;antioxidant;anti-diabetes;anti-Alzheimer;phytochemical profile;drug discovery;medicinal plants
語言 en
ISSN
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 San-Lang Wang
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
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