Screening and elucidation of chemical structures of novel mammalian α-glucosidase inhibitors targeting anti-diabetes drug from herbals used by E De ethnic tribe in Vietnam
學年 111
學期 2
出版(發表)日期 2023-05-17
作品名稱 Screening and elucidation of chemical structures of novel mammalian α-glucosidase inhibitors targeting anti-diabetes drug from herbals used by E De ethnic tribe in Vietnam
作品名稱(其他語言)
著者 Nguyen VB, Wang SL, Phan TQ, Pham THT, Hung TH, Liaw CC, Nguyen AD
單位
出版者
著錄名稱、卷期、頁數 Pharmaceuticals 16(05), 756
摘要 Among ten extracts of indigenous medicinal plants, the MeOH extract of Terminalia triptera Stapf. (TTS) showed the most efficient mammalian α-glucosidase inhibition for the first time. The data of screening bioactive parts used indicated that the TTS trunk bark and leaves extracts demonstrated comparable and higher effects compared to acarbose, a commercial anti-diabetic drug, with half-maximal inhibitory concentration (IC50) values of 181, 331, and 309 µg/mL, respectively. Further bioassay-guided purification led to the isolation of three active compounds from the TTS trunk bark extract and identified as (−)-epicatechin (1), eschweilenol C (2), and gallic acid (3). Of these, compounds 1 and 2 were determined as novel and potent mammalian α-glucosidase inhibitors. The virtual study indicated that these compounds bind to α-glucosidase (Q6P7A9) with acceptable RMSD values (1.16–1.56 Å) and good binding energy (DS values in the range of −11.4 to −12.8 kcal/mol) by interacting with various prominent amino acids to generate five and six linkages, respectively. The data of Lipinski’s rule of five and absorption, distribution, metabolism, excretion and toxicity (ADMET)-based pharmacokinetics and pharmacology revealed that these purified compounds possess anti-diabetic drug properties, and the compounds are almost not toxic for human use. Thus, the findings of this work suggested that (−)-epicatechin and esc
關鍵字 Medicinal plants;Terminalia triptera Stapf.;α-glucosidase inhibitors;(−)-epicatechin;eschweilenol C;Q6P7A9;E De Ethnic Tribe;virtual study
語言 en
ISSN 1424-8247
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 San-Lang, Wang
審稿制度
國別 CHE
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/124120 )