Microorganism-derived molecules as enzyme inhibitors to target Alzheimer's diseases pathways
學年 111
學期 2
出版(發表)日期 2023-04-12
作品名稱 Microorganism-derived molecules as enzyme inhibitors to target Alzheimer's diseases pathways
著者 Thi Hanh Nguyen; San-Lang Wang; Van Bon Nguyen
著錄名稱、卷期、頁數 Pharmaceuticals 16(4)
摘要 Alzheimer’s disease (AD) is the most common form of dementia. It increases the risk of other serious diseases and causes a huge impact on individuals, families, and socioeconomics. AD is a complex multifactorial disease, and current pharmacological therapies are largely based on the inhibition of enzymes involved in the pathogenesis of AD. Natural enzyme inhibitors are the potential sources for targeting AD treatment and are mainly collected from plants, marine organisms, or microorganisms. In particular, microbial sources have many advantages compared to other sources. While several reviews on AD have been reported, most of these previous reviews focused on presenting and discussing the general theory of AD or overviewing enzyme inhibitors from various sources, such as chemical synthesis, plants, and marine organisms, while only a few reviews regarding microbial sources of enzyme inhibitors against AD are available. Currently, multi-targeted drug investigation is a new trend for the potential treatment of AD. However, there is no review that has comprehensively discussed the various kinds of enzyme inhibitors from the microbial source. This review extensively addresses the above-mentioned aspect and simultaneously updates and provides a more comprehensive view of the enzyme targets involved in the pathogenesis of AD. The emerging trend of using in silico studies to discover drugs concerning AD inhibitors from microorganisms and perspectives for further experimental studies are also covered here.
關鍵字 Alzheimer’s disease;enzyme inhibitors;microbial source;virtual study;ChE;secretase;GSK-3β;MAO;PKC;PDE
語言 en
ISSN 1424-8247
期刊性質 國外
收錄於 SCI
通訊作者 San-Lang, Wang
國別 CHE
出版型式 ,電子版

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/123410 )