A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
學年 110
學期 2
出版（發表）日期 2022-07-06
作品名稱 A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
作品名稱（其他語言）
著者 Yang, L.-X.; Liu, Y.-C.; Cho, C.-H.; Chen, Y.-R.; Yang, C.-S.; Lu, Y.-L.; Zhang, Z.; Tsai, Y.-T.; Chin, Y.-C.; Yu, J.; Pan, H.-M.; Jiang, W.-R.; Chia, Z.-C.; Huang, W.-S.; Chiu, Y.-L.; Sun, C.-K.; Huang, Y.-T.; Chen, L.-M.; Wong, K.-T.; Huang, H.-M.; Chen, C.-H.*; Chang, Y. J.*; Huang, C.-C.*; Liu, T.-M. *
單位
出版者
著錄名稱、卷期、頁數 Journal of Nanobiotechnology 20, 311
摘要 The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.
關鍵字 Polymer;Near-infrared red;Optoelectronic material;Photodynamic therapy;Theranostic;Multiphoton microscopy;Fluorescence imaging
語言 en
ISSN 1477-3155
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 GBR
公開徵稿
出版型式 ,電子版,紙本
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/123403 )