Effects of swimming training on myocardial protection in rats
學年 110
學期 1
出版(發表)日期 2022-01-31
作品名稱 Effects of swimming training on myocardial protection in rats
著者 Chang-Chi Lai, Chia-Yu Tang, Szu-Kai Fu, Wei-Chin Tseng, Kuo-Wei Tseng
著錄名稱、卷期、頁數 Biomedical Reports, 16(19)
摘要 Swimming is important for promoting and maintaining health, as it can increase the efficiency of the cardiovascular system and decrease the occurrence of cardiovascular diseases. The objective of the present study was to examine whether swimming training could decrease myocardial injury in rats caused by myocardial ischemia/reperfusion (I/R). Sprague-Dawley rats were randomized into four groups, namely the Sham, coronary artery occlusion, swimming training and ischemic preconditioning (IPC) groups. Myocardial I/R was induced in anesthetized male Sprague-Dawley rats by a 40-min occlusion followed by a 3-h reperfusion of the left anterior descending coronary artery. The rats were sacrificed after surgery and their hearts were examined. The results demonstrated that the number of TUNEL-positive nuclei and degree of caspase-3 activation were both significantly increased in the myocardium following myocardial I/R in rats, indicating increased cardiomyocyte apoptosis. On the other hand, swimming training decreased the serum levels of creatine phosphokinase, lactate dehydrogenase and cardiac troponin I, and was associated with reduced histological damage and myocardial infarct size. Furthermore, swimming training also reduced TNF-α levels, caspase-3 activation and enhanced Bcl-2 activation, which decreased the number of apoptotic cells in the myocardium. The findings of the present study showed that swimming training and IPC could similarly decrease myocardial injury following myocardial I/R, and may therefore be used as exercise training to effectively prevent myocardial injury.
關鍵字 swimming training;myocardial ischemia-reperfusion;ischemic precondition;coronary artery occlusion;apoptosis
語言 en
ISSN 2049-9442;2049-9434
期刊性質 國外
收錄於 SCI Scopus
通訊作者 Kuo-Wei Tseng
國別 GRC
出版型式 ,電子版,紙本

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/123182 )

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