教師資料查詢 | 類別: 期刊論文 | 教師: 曾耀霆TSENG, YAO-TING (瀏覽個人網頁)

標題:Progression of precancerous lesions to oral cancer: results based on the Taiwan National Health Insurance Database
學年101
學期2
出版(發表)日期2013/05/01
作品名稱Progression of precancerous lesions to oral cancer: results based on the Taiwan National Health Insurance Database
作品名稱(其他語言)English
著者Ie-BinLian; Yao-TingTseng; Che-ChunSu; Kuo-YangTsai
單位
出版者
著錄名稱、卷期、頁數Oral Oncology 49(5), p.427-430
摘要Background
Oral cancer (OC) is the leading cause of death from cancer in men between the ages of 25 and 44 in Taiwan. The survival rate for the last stage of OC is <20% while that for the earliest stage is >75%, which suggests the importance of the diagnosis of oral precancerous lesions (OPLs) in reducing OC mortality. The aim of this study was to analyze the time to OC event after OPL diagnosis, and to suggest the surveillance period necessary according to OPL type.

Materials and methods
This was a retrospective cohort study based on 1.0 million people randomly selected from the Taiwan National Health Insurance Database, which provided data on 3058 adult male patients aged ⩾20 years who were diagnosed with OPL for the first time between 1996 and 2009. The patient population was divided into two groups according to the type of lesion: oral submucous fibrosis (OSF) or oral leukoplakia (OLE). Age-standardized incidence rate (ASIR) and hazards rate (HR) were then estimated.

Results
The ASIR for OPL showed an increasing trend over the study period, the main contributor to this being OSF. The OSF group demonstrated a higher OC incidence rate than the OLE group.

Conclusion
Patients with both OLE and OSF carry a higher risk for OC than those with either OLE or OSF alone, and they may also experience malignant transformation at an earlier date (mostly within 5 years). The 5- and 10-year OC rate for both OLE and OSF was found to be 5% and around 10%, respectively. However, 10 years after the diagnosis of OPL, OSF carries a higher risk of developing into OC than OLE.
關鍵字Premalignant lesions;Oral submucous fibrosis;Oral leukoplakia;Epidemiology
語言英文
ISSN1368-8375;1879-0593
期刊性質國外
收錄於SCI;
產學合作
通訊作者Su, C. C., & Tsai, K. Y.
審稿制度
國別英國
公開徵稿
出版型式,電子版,紙本
SDGs
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