Physicochemical characteristics of thermo-responsive gelatin membranes containing carboxymethyl chitosan and poly(N‑isopropylacrylamide-co-acrylic acid)
學年 109
學期 2
出版（發表）日期 2021-04-15
作品名稱 Physicochemical characteristics of thermo-responsive gelatin membranes containing carboxymethyl chitosan and poly(N‑isopropylacrylamide-co-acrylic acid)
作品名稱（其他語言）
著者 Yi-Cheng Huang; Chia-Tien Lee; Trong-Ming Don
單位
出版者
著錄名稱、卷期、頁數 Journal of Polymer Research 28, 173
摘要 Gelatin has many superior biological properties and can absorb a large volume of water to form hydrogels, making it a promising material for skin wound care. In this study, gel membranes were prepared based on gelatin and added with different amounts of the synthesized carboxymethyl chitosan (CMCS) and poly(N-isopropylacrylamide-co-acrylic acid) (P(NI-co-AA)) copolymer for providing antibacterial and thermo-responsive properties, respectively. The synthesized CMCS had a degree of carboxymethyl substitution at 0.77 and the P(NI-co-AA) had an AA content of 5.7 mol %. Both CMCS and P(NI-co-AA) had carboxylate groups that could further provide ionic-crosslinking sites for the membranes. Though the P(NI-co-AA) copolymer had a higher phase transition temperature than poly(N-isopropylacrylamide) (PNIPAAm) owing to its hydrophilic carboxylate groups, the prepared gelatin/CMCS/P(NI-co-AA) membranes had similar phase transition temperatures to the PNIPAAm at around 30.5 − 32.4 °C because of ionic crosslinking. Moreover, the equilibrium swelling ratio and water vapor transmission rate of the gel membranes were in the range of 769 − 1226% and 1678 − 2496 g/m2- day, respectively. These membranes could promote cell proliferation of human keratinocytes (HaCaT) and mouse fibroblasts (L-929), indicating they were non-toxic to the cells. They also had antimicrobial properties against S. aureus and E. coli, where the antibacterial efficacy increased with increasing the CMCS content. These hydrogel membranes had good biocompatibility, suitable swelling ratio and water vapor transmission rate, antibacterial and thermo-responsive properties. Therefore, they have potential to be applied as functional wound dressing material.
關鍵字 Gelatin;Carboxymethyl chitosan;Poly(N-isopropylacrylamide);Hydrogel;Thermo-responsive;Wound dressing
語言 en_US
ISSN 1022-9760; 1572-8935
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Trong-Ming Don
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/121475 )