教師資料查詢 | 類別: 期刊論文 | 教師: 施增廉 SHIH, TZENGE-LIEN (瀏覽個人網頁)

標題:A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
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出版(發表)日期2021/08/27
作品名稱A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI
作品名稱(其他語言)
著者Tzenge-Lien Shih; Kuan-Hung Lin; Ray-Jade Chen; Ting-Yu Chen; Wei-Ting Kao; Jen-Wei Liu; Hsueh-Hsiao Wang; Hsien-Yu Peng; Yu-Yo Sun; Wan-Jung Lu
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著錄名稱、卷期、頁數Journal of Cellular and Molecular Medicine 25(19), p.9434-9446
摘要Naphthalimide derivatives have multiple biological activities, including antitumour and anti-inflammatory activities. We previously synthesized several naphthalimide derivatives; of them, compound 5 was found to exert the strongest inhibitory effect on human DNA topoisomerase II activity. However, the effects of naphthalimide derivatives on platelet activation have not yet been investigated. Therefore, the mechanism underlying the antiplatelet activity of compound 5 was determined in this study. The data revealed that compound 5 (5–10 μM) inhibited collagen- and convulxin- but not thrombin- or U46619-mediated platelet aggregation, suggesting that compound 5 is more sensitive to the inhibition of glycoprotein VI (GPVI) signalling. Indeed, compound 5 could inhibit the phosphorylation of signalling molecules downstream of GPVI, followed by the inhibition of calcium mobilization, granule release and GPIIb/IIIa activation. Moreover, compound 5 prevented pulmonary embolism and prolonged the occlusion time, but tended to prolong the bleeding time, indicating that it can prevent thrombus formation but may increase bleeding risk. This study is the first to demonstrate that the naphthalimide derivative compound 5 exerts antiplatelet and antithrombotic effects. Future studies should modify compound 5 to synthesize more potent and efficient antiplatelet agents while minimizing bleeding risk, which may offer a therapeutic potential for cardiovascular diseases.
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語言英文(美國)
ISSN1582-4934
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收錄於SCI;
產學合作
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國別英國
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