教師資料查詢 | 類別: 期刊論文 | 教師: 謝仁傑HSIEH, JEN-CHIEH (瀏覽個人網頁)

標題:Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines
學年109
學期1
出版(發表)日期2020/11/13
作品名稱Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines
作品名稱(其他語言)
著者Hung-Kai Wang; Yu-Lun Chio; Gangaram Pallikonda; Hsyueh-Liang Wu; Haw-Lih Su; Jen-Chieh Hsieh(謝仁傑)
單位
出版者
著錄名稱、卷期、頁數Molecules 25(22), 5303
摘要A synthetic approach to quinindoline derivatives by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure.
關鍵字copper-catalyzed;quinindoline;natural alkaloid;N-heterocycle;cyclization
語言英文
ISSN1420-3049
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別瑞士
公開徵稿
出版型式,電子版
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