Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines
學年 109
學期 1
出版(發表)日期 2020-11-13
作品名稱 Copper-Catalyzed Dual Cyclization for the Synthesis of Quinindolines
作品名稱(其他語言)
著者 Hung-Kai Wang; Yu-Lun Chio; Gangaram Pallikonda; Hsyueh-Liang Wu; Haw-Lih Su; Jen-Chieh Hsieh(謝仁傑)
單位
出版者
著錄名稱、卷期、頁數 Molecules 25(22), 5303
摘要 A synthetic approach to quinindoline derivatives by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure.
關鍵字 copper-catalyzed;quinindoline;natural alkaloid;N-heterocycle;cyclization
語言 en
ISSN 1420-3049
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度
國別 CHE
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/120973 )