教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Explore the Effects of Pharmacological, Psychosocial, and Alternative /Complementary Interventions in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Meta-regression Approach
學年
學期
出版(發表)日期2021/06/04
作品名稱Explore the Effects of Pharmacological, Psychosocial, and Alternative /Complementary Interventions in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Meta-regression Approach
作品名稱(其他語言)
著者Kung-Han Yang, Yue-Cune Chang, Ruu-Fen Tzang, Hsien-Yuan Lane
單位
出版者
著錄名稱、卷期、頁數International Journal of Neuropsychopharmacology, pyab034
摘要Background Till now, there have been various therapies for attention-deficit/hyperactivity disorder
(ADHD), but the previous meta-analysis of ADHD efficacy remains unclear. This study aims to
systemically meta-regress the effect sizes of psychostimulant pharmacotherapy (methylphenidate and
lisdexamfetamine), non-stimulant pharmacotherapy (atomoxetine and alpha-2 agonists), psychosocial
therapy (parental behavioral therapy [PBT]), combination therapy (psychostimulant plus PBT), and
alternative/complementary interventions to determine the right treatment for ADHD. Methods We
searched various ADHD interventions from the MEDLINE and PubMed databases (National Center
for Biotechnology Information) between January 1, 1980 and July 30, 2018. Following the metaanalysis of random effects, the meta-regression analyses were used to explore factors potentially
influencing treatment efficacy. The confounding variables included type of treatment, type of study,
age, type of symptom scale used, and year of publication. Results A total of 107 trials (N = 9883
participants) were included. After adjustment, compared to the psychostimulant therapy (28 trial,
2134 participants), non-stimulant pharmacotherapy (28 trials, 4991 participants) and
alternative/complement intervention (25 trials, 1195 participants) were less effective by the effect
sizes (ES) of -0.384 (p = 0.004) and -0.419 (p = 0.028) respectively. However, compared to
psychostimulant, PBT (19 trials, 1122 participants; ES = -0.308, p = 0.095) and combination of
psychostimulant and PBT (7 trials, 441participants; ES = -0.196, p = 0.209) did not differ
significantly. Conclusions Psychostimulant therapy surpassed non-stimulant pharmacotherapy and
alternative/complement intervention. Psychostimulant therapy, PBT, and combination of
psychostimulant therapy and PBT appear to be similar in efficacy according to this meta-regression.
關鍵字ADHD;treatment efficacy;pharmacotherapy;behavior therapy;meta-regression
語言英文(美國)
ISSN
期刊性質國外
收錄於SCI;
產學合作
通訊作者Ruu-Fen Tzang and Hsien-Yuan Lane
審稿制度
國別美國
公開徵稿
出版型式,電子版
相關連結
SDGs
Google+ 推薦功能,讓全世界都能看到您的推薦!