教師資料查詢 | 類別: 期刊論文 | 教師: 王三郎 WANG SAN-LANG (瀏覽個人網頁)

標題:Bio-processing of marine chitinous wastes for the production of bioactive prodigiosin
學年
學期
出版(發表)日期2021/05/24
作品名稱Bio-processing of marine chitinous wastes for the production of bioactive prodigiosin
作品名稱(其他語言)
著者Nguyen TH; Wang SL; Nguyen DM; Nguyen AD; Nguyen TH; Doan MD; Ngo VA; Doan CT; Kuo YH; Nguyen VB
單位
出版者
著錄名稱、卷期、頁數Molecules 26 (11), 3138
摘要Recently, microbial prodigiosin (PG) has received much attention due to its numerous
beneficial applications. The aim of this study was to establish the bioprocessing of marine chitinous
wastes (MCWs) for the cost‐effective preparation of PG. Of the MCWs, demineralized shrimp shell
powders (de‐SSP) were found to be a potential source of carbon/nitrogen (C/N) for PG production
by bacterial fermentation using Serratia marcescens strains. Further, PG scale‐up production was in‐
vestigated in a 15 L bioreactor system, and the highest yield (6200 mg/L) was achieved during fer‐
mentation using 5 L of a novel‐designed culture broth that included 1.60% C/N sources (a de‐SSP/ca‐
sein ratio of 7/3), 0.02% K2SO4, and 0.05% K2HPO4, with an initial pH of 6–7. Fermentation was con‐
ducted in the dark at 27.5 °C for 8.0 h. This study was the first to report on the utilization of shrimp
wastes for cost‐effective, large‐scale (5 L/pilot) PG production with high productivity (6200 mg/L)
in a short cultivation time. The combination of 0.02% K2SO4 and 0.05% K2HPO4 was also found to
be a novel salt composition that significantly enhanced PG yield. The red compound was purified
and confirmed as PG after analyzing its HPLC profile, mass, and UV/vis spectra. The purified PG
was then tested for its bioactivities and showed effective anticancer activities, moderated antioxi‐
dant activities, and novel anti‐NO effects.
關鍵字prodigiosin;Serratia marcescens;shrimp shells;bioreactor;fermentation;antioxidants;anti‐NO activity
語言英文
ISSN
期刊性質國外
收錄於SCI;
產學合作
通訊作者San-Lang, Wang
審稿制度
國別瑞士
公開徵稿
出版型式,電子版
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