教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
學年
學期
出版(發表)日期2021/05/11
作品名稱Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model
作品名稱(其他語言)
著者Guo-Shu Huang; Yi-Jen Peng; Yu-Juei Hsu; Herng-Sheng Lee; Yue-Cune Chang; Shih-Wei Chiang; Yi-Chih Hsu; Ying-Chun Liu; Ming-Huang Lin; Chao-Ying Wang
單位
出版者
著錄名稱、卷期、頁數Scientific Reports 11(1), 9924
摘要The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague-Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, kel and kep) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability kep values from 16 weeks (p < 0.05), lower venous washout kel value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression.
關鍵字Chronic kidney disease;Magnetic resonance imaging;Musculoskeletal system
語言英文(美國)
ISSN2045-2322
期刊性質國外
收錄於SCI;
產學合作
通訊作者Chao-Ying Wang
審稿制度
國別英國
公開徵稿
出版型式,電子版
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