教師資料查詢 | 類別: 期刊論文 | 教師: 李世元 ADAM SHIH-YUAN LEE (瀏覽個人網頁)

標題:A sensitive bithiophene-based biosensor for interferon-gamma characterization and analysis
學年
學期
出版(發表)日期2014/11/28
作品名稱A sensitive bithiophene-based biosensor for interferon-gamma characterization and analysis
作品名稱(其他語言)
著者P.I. Tsai; S.S. Lee; S.T. Chou; C.M. Jan; Y.T. Chang; A.S.Y. Lee; C.K. Lee
單位
出版者
著錄名稱、卷期、頁數Thin Solid Films 571(3), p.473-477
摘要Real-time, label-free monitoring offers a wide range of applications to the biotech field. We developed an integrated bio-sensing platform which adapts a circular polarization interferometry configuration and a phase modulated ellipsometer to improve the performance of biomolecular measurements. An bithiophene-based conductive linker-5′-(mercapto)-[2, 2′-bithiophene]-5-carboxylic acid was developed for detecting antibody–antigen interactions. In this study, the biomarker interferon-gamma (IFN-γ), one of the most important indicators of tuberculosis, was chosen to test and verify the sensitivity of our measurement system. Our experimental results showed that an increase in the concentration of the IFN-γ (64 pM to 1 μM) was usually accompanied by a phase increase. This result is good evidence that our biosensing system can be useful for analyzing biomolecular interactions.
關鍵字Surface plasmon resonance;Ellipsometry;Interferon-gamma;Phase-interrogation;Bithiophene
語言英文
ISSN1879-2731
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別荷蘭
公開徵稿
出版型式,電子版
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