Synthesis of multiple boron-containing analogs via Ugi-4CR
學年 107
學期 1
出版（發表）日期 2018-10-24
作品名稱 Synthesis of multiple boron-containing analogs via Ugi-4CR
作品名稱（其他語言）
著者 Yi-Wei Chen; Pei-Chun Liao; Yu-Xuan Zhang; Shang-Yi Yeh; Yu-Hsuan Wu; Shuo-Bei Qiu; Pei-Ni Tsai; Zhuo Xin; Yen-Yu Ting; Hsien-Chi Chen; Siu-Fung Cheung; Chen-Yun Hsu; Wan-Hsing Lien; Po-Shen Pan
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates 45, p.103–118
摘要 One of the most significant challenges in boron neutron capture therapy (BNCT) is to have an ideal boron delivery agent which can deliver sufficient numbers of boron atoms to designated tumor cells. In this work, mild synthetic conditions for synthesis of dipeptidyl multiple boron-containing analogs under microwave-assisted condition were investigated. The results showed that the reaction generally took place at 50 °C, but higher reaction temperature was required when a fluorinated building block was used. The resulting peptidyl skeletons generated by Ugi four-component reaction resemble basic cell metabolites and could potentially be used as alternative replacements for current boron carrier agents in BNCT.
關鍵字 Boron neutron capture therapy;Boron;Multicomponent reaction;Ugi reaction
語言 en_US
ISSN 1568-5675
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Po-Shen Pan
審稿制度 是
國別 DEU
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/120754 )

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