教師資料查詢 | 類別: 期刊論文 | 教師: 潘伯申 PO-SHEN PAN (瀏覽個人網頁)

標題:Synthesis of multiple boron-containing analogs via Ugi-4CR
學年
學期
出版(發表)日期2018/10/24
作品名稱Synthesis of multiple boron-containing analogs via Ugi-4CR
作品名稱(其他語言)
著者Yi-Wei Chen; Pei-Chun Liao; Yu-Xuan Zhang; Shang-Yi Yeh; Yu-Hsuan Wu; Shuo-Bei Qiu; Pei-Ni Tsai; Zhuo Xin; Yen-Yu Ting; Hsien-Chi Chen; Siu-Fung Cheung; Chen-Yun Hsu; Wan-Hsing Lien; Po-Shen Pan
單位
出版者
著錄名稱、卷期、頁數Research on Chemical Intermediates 45, p.103–118
摘要One of the most significant challenges in boron neutron capture therapy (BNCT) is to have an ideal boron delivery agent which can deliver sufficient numbers of boron atoms to designated tumor cells. In this work, mild synthetic conditions for synthesis of dipeptidyl multiple boron-containing analogs under microwave-assisted condition were investigated. The results showed that the reaction generally took place at 50 °C, but higher reaction temperature was required when a fluorinated building block was used. The resulting peptidyl skeletons generated by Ugi four-component reaction resemble basic cell metabolites and could potentially be used as alternative replacements for current boron carrier agents in BNCT.
關鍵字Boron neutron capture therapy;Boron;Multicomponent reaction;Ugi reaction
語言英文(美國)
ISSN1568-5675
期刊性質國外
收錄於SCI;
產學合作
通訊作者Po-Shen Pan
審稿制度
國別德國
公開徵稿
出版型式,電子版
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