Increased Cyclin T1 Expression as a Favorable Prognostic Factor in Treating Gastric Adenocarcinoma
學年 104
學期 1
出版（發表）日期 2015-09-25
作品名稱 Increased Cyclin T1 Expression as a Favorable Prognostic Factor in Treating Gastric Adenocarcinoma
作品名稱（其他語言）
著者 Jong-Shiaw Jin; Lien-Fu Lin; Jui-Chang Chen; Chia-Chi Huang; Jeng-Horng Sheu; Wenlung Chen; Tang-Yi Tsao; Chih-Wei Hsu
單位
出版者
著錄名稱、卷期、頁數 Oncology Letters 10(6), p.3712-3718
摘要 The expression of cyclin A, B1, D1 and E in gastric adenocarcinoma is known to be associated with clinical outcome. However, few studies have investigated the role of cyclin T1 and cyclin‑dependent kinase 9 (CDK9) in gastric adenocarcinoma. Therefore, this study assessed the clinical significance of cyclin T1 and CDK9 expression in gastric adenocarcinoma. A total of 39 gastric adenocarcinoma patients received either radical total or distal gastrectomy in this study. Surgical tissue slides were stained with CDK9 and cyclin T1 antibodies, and immunohistochemistry scores and disease‑free survival (DFS) rates were analyzed. Among the 19 patients with tumor‑recurrent or distant metastasis, 16 were recorded as exhibiting low expression of cyclin T1. The remaining three patients exhibited high expression of the antibody. The results of patients with a higher T stage, N stage and tumor grade were less favorable. For patients with adenocarcinoma, the percentage of tissue slides stained with cyclin T1 was significantly higher than for those with normal stomach epithelia. The DFS rates of patients with low expression of cyclin T1 were significantly associated with poorer DFS rates. In conclusion, high expression of cyclin T1 is a favorable prognostic factor in treating patients with stomach adenocarcinoma.
關鍵字 gastric adenocarcinoma;cyclin T1;cyclin-dependent kinase 9;disease-free survival
語言 en_US
ISSN 1792-1082
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 GRC
公開徵稿
出版型式 ,電子版,紙本
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