Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease
學年 105
學期 2
出版（發表）日期 2017-04-19
作品名稱 Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease
作品名稱（其他語言）
著者 Chia-Chi Huang; Ciro Isidoro
單位
出版者
著錄名稱、卷期、頁數 Journal of Alzheimer's Disease 57(4), p.1145-1156
摘要 The continuous increasing rate of patients suffering of Alzheimer’s disease (AD) worldwide requires the adoption of novel techniques for non-invasive early diagnosis and monitoring of the disease. Here we review the various Raman spectroscopic techniques, including Fourier Transform-Raman spectroscopy, surface-enhanced Raman scattering spectroscopy, coherent anti-Stokes Raman scattering spectroscopy, and confocal Raman microspectroscopy, that could be used for the diagnosis of AD. These techniques have shown the potential to detect AD biomarkers, such as the amyloid-β peptide and the tau protein, or the neurotransmitters involved in the disease (e.g., Glutamate and γ-Aminobutyric acid), or the typical structural alterations in specific brain areas. The possibility to detect the specific biomarkers in liquid biopsies and to obtain high resolution 3D microscope images of the affected area make the Raman spectroscopy a valuable ally in the early diagnosis and monitoring of AD.
關鍵字 Alzheimer's disease;amyloid-β peptide;brain tissue;diagnosis;Raman spectroscopy;tau protein
語言 en_US
ISSN 1875-8908
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
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