Dual down-regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells.
學年 109
學期 2
出版（發表）日期 2021-05-01
作品名稱 Dual down-regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells.
作品名稱（其他語言）
著者 Chuang TC; Wu K; Lin YY; Kuo HP; Kao MC; Wang V; Hsu SC; Lee SL
單位
出版者
著錄名稱、卷期、頁數 Environmental toxicology 36(5), p. 737-747
摘要 The overexpression of EGFR and/or ErbB2 occurs frequently in ovarian cancers and is associated with poor prognosis. The purpose of this study was to examine the anticancer effects and molecular mechanisms of berberine on human ovarian cancer cells with different levels of EGFR and/or ErbB2. We found that berberine reduced the motility and invasiveness of ovarian cancer cells. Berberine depleted both EGFR and ErbB2 in ovarian cancer cells. Furthermore, berberine suppressed the activation of the EGFR and ErbB2 downstream targets cyclin D1, MMPs, and VEGF by down‐regulating the EGFR‐ErbB2/PI3K/Akt signaling pathway. The berberine‐mediated inhibition of MMP‐2 and MMP‐9 activity could be rescued by co‐treatment with EGF. Finally, we demonstrated that berberine induced ErbB2 depletion through ubiquitin‐mediated proteasome degradation. In conclusion, the suppressive effects of berberine on the ovarian cancer cells that differ in the expression of EGFR and ErbB2 may be mediated by the dual depletion of EGFR and/or ErbB2.
關鍵字 berberine;EGFR;ErbB2;metastatic potential;ovarian cancer
語言 en
ISSN 1522-7278
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Chuang TC
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版,紙本
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