||Background: Impaired kidney function is the hallmark of chronic kidney disease (CKD), and is associated with
increased risk of all-cause mortality in the elderly. In the present cross-sectional population-based study, we aimed
to evaluate the associations between lifestyle factors (exercise habit, alcohol consumption, smoking history, and
betel nut chewing) and decreased kidney function.
Methods: The data from the Taipei City Elderly Health Examination Database (2006 to 2012) were extracted.
Associations between risk factors and reduced estimated Glomerular filtration rate (eGFR) were evaluated by
regression and stratification analyses.
Results: A total of 297,603 participants were included in the final analysis, and 29.7% of them had reduced eGFR.
Smoking was significantly associated with an elevated risk of reduced eGFR. While, physical exercise conferred to a
significantly decreased adjusted odds ratio (aOR) in reduced eGFR (regular exercise, aOR = 0.79; occasional exercise,
aOR = 0.87). Furthermore, the protective effect of exercise habit against reduced eGFR was not affected by
comorbid conditions, such as hypertension, diabetes, obesity, and cardiovascular disease.
Conclusions: Engaging in physical exercise was beneficially associated with reduced eGFR in older individuals.
Longitudinal or prospective studies are warranted for confirmation and extrapolation of the current findings.