Surface-functionalized layered double hydroxide nanocontainers as bile acid sequestrants for lowering hyperlipidemia
學年 109
學期 1
出版（發表）日期 2020-11-30
作品名稱 Surface-functionalized layered double hydroxide nanocontainers as bile acid sequestrants for lowering hyperlipidemia
作品名稱（其他語言）
著者 Chiao-Wen Lin; Shi-Xiang Lin; Ranjith Kumar Kankala; Prabhakar Busa; Jin-Pei Deng; Sheng-I Lue; Chen-Lun Liu; Ching-Feng Weng; Chia-Hung Lee
單位
出版者
著錄名稱、卷期、頁數 International Journal of Pharmaceutics 590, 119921
摘要 The surface modification of two-dimensional (2D) nanocontainers with versatile chemical functionalities offers enormous advantages in medicine owing to their altered physicochemical properties. In this study, we demonstrate the fabrication of surface-functionalized layered double hydroxides (LDHs) towards their use as effective intestinal bile acid sequestrants. To demonstrate these aspects, the LDHs are initially modified with an amino silane, N1-(3-trimethoxysilylpropyl) diethylenetriamine (LDHs-N3), which, on the one hand, subsequently used for the fabrication of the dendrimer by repetitive immobilization of ethylene diamine using methyl acrylate as a spacer. On the other hand, these surface-functionalized LDHs are wrapped with an anionic enteric co-polymer to not only prevent the degradation but also increase the stability of these 2D nanoplates in an acidic environment of the stomach to explore the in vivo efficacy. In vitro cholic acid adsorption results showed that these surface-functionalized LDHs displayed tremendous adsorption ability of bile salt. Consequently, the bile salt adsorption results in vivo in mice confirmed that the enteric polymer-coated diethylenetriamine silane-modified LDHs, resulting in the reduced cholesterol by 8.2% in the high fat diet-fed mice compared to that of the oil treatment group with augmented 28% of cholesterol, which gained weight by 6.7% in 4 weeks. Notably, the relative organ (liver and kidney) weight analysis and the tissue section of histology results indicated that the modified LDHs showed high biocompatibility in vivo. Together, our findings validate that these surface-functionalized 2D nanoplates have great potential as effective intestinal bile acid sequestrants.
關鍵字 Bile acid sequestrants;Two-dimensional;Cholesterol;Layered double hydroxides;Nanoparticles
語言 en
ISSN 1873-3476
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 NLD
公開徵稿
出版型式 ,電子版
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