Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy
學年 108
學期 1
出版（發表）日期 2020-01-20
作品名稱 Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy
作品名稱（其他語言）
著者 Ai-Ru Hsieh(謝璦如); Yu-Chuen Huang; Ya-Fei Yang; Jane-Ming Lin; Hui-Ju Lin; Ya-Wen Chang; Chia-Ming Wu; Wen-Ling Liao; Fuu-Jen Tsai
單位
出版者
著錄名稱、卷期、頁數 BMJ Open Diabetes Research & Care 8(1), e000727
摘要 Objective Diabetic nephropathy (DN) and diabetic retinopathy (DR) comprise major microvascular complications of diabetes that occur with a high concordance rate in patients and are considered to potentially share pathogeneses. In this case-control study, we sought to investigate whether DR-related single nucleotide polymorphisms (SNPs) exert pleiotropic effects on renal function outcomes among patients with diabetes. Research design and methods A total of 33 DR-related SNPs were identified by replicating published SNPs and via a genome-wide association study. Furthermore, we assessed the cumulative effects by creating a weighted genetic risk score and evaluated the discriminatory and prediction ability of these genetic variants using DN cases according to estimated glomerular filtration rate (eGFR) status along with a cohort with early renal functional decline (ERFD). Results Multivariate logistic regression models revealed that the DR-related SNPs afforded no individual or cumulative genetic effect on the nephropathy risk, eGFR status or ERFD outcome among patients with type two diabetes in Taiwan. Conclusion Our findings indicate that larger studies would be necessary to clearly ascertain the effects of individual genetic variants and further investigation is also required to identify other genetic pathways underlying DN.
關鍵字 diabetic nephropathy;diabetic retinopathy;pleiotropic effect
語言 en_US
ISSN 2052-4897
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 是
國別 GBR
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/118174 )