Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma
學年 105
學期 2
出版（發表）日期 2017-02-07
作品名稱 Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma
作品名稱（其他語言）
著者 Hsieh Ai-Ru; Chu CM; Yeh CT; Lin HG; Wan SY; Chen YC; Hsu CL; Lin SM; Fann Cathy SJ; Dar-In Tai
單位
出版者
著錄名稱、卷期、頁數 World Journal of Gastroenterology 23(5), p.876-884
摘要 AIM To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives. METHODS We evaluated non-genetic factors associated with HBV replication in relatives of patients with HCC. Relatives of 355 HCC cases were interviewed using a structured questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation (P = 0.0076), index generation (P = 0.0044), mothers positive for HBsAg (P = 0.0007), and HBsAg-positive index cases (P = 5.98 × 10-8) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBsAg-positive relatives. Parent generation (P = 0.0359) and sex (P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBsAg-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46 (58.7%) families. Male offspring of HBsAg-positive mothers (P = 0.024) and older siblings were associated with high viral load. CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.
關鍵字 Familial generation;Sex;Hepatitis B virus;Perinatal infection;Viral replication
語言 zh_TW
ISSN
期刊性質 國內
收錄於
產學合作
通訊作者
審稿制度 否
國別 TWN
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/117106 )