Guided bone regeneration activity of different calcium phosphate/chitosan hybrid membrane
學年 107
學期 2
出版（發表）日期 2019-04-01
作品名稱 Guided bone regeneration activity of different calcium phosphate/chitosan hybrid membrane
作品名稱（其他語言）
著者 Yau-Hung, Chen; Hung-Yin Tai; Earl Fu; Trong-Ming Don
單位
出版者
著錄名稱、卷期、頁數 Intl. J. Biol. Macromol 126, p.159-169
摘要 To fulfill the properties of membrane for guided bone tissue regeneration, chitosan (CS) and calcium phosphates were blended to produce porous hybrid membranes by lyophilization. We synthesized three different calcium phosphates: calcium deficient hydroxyapatite (CDHA), biphasic calcium phosphate (BCP) and β‑tricalcium phosphate (TCP) by a reverse emulsion method followed by calcination, and compared their efficacy on bone regeneration. The CDHA/CS, BCP/CS, and TCP/CS membranes had an interconnected pore structure with porosity of 91–95% and pore size of 102–147 μm. These hybrid membranes could promote the permeability and adhesiveness to bone cells as demonstrated by in-vitro cell culture of primary osteoblast. Particularly, the CDHA/CS and BCP/CS could further increase the cell attachment and differentiation, whereas the BCP/CS and TCP/CS could enhance cell proliferation. Finally, these hybrid membranes were assessed for guided bone regeneration in the critical-size calvarial bone defects created in SD rats. Histological and histomorphometric analyses revealed that the BCP/CS membrane had the most effective bone regeneration compared to the other two hybrid membranes. At three-week post-surgery, the BCP/CS membrane could enhance new bone generation up to 57% of the original bone defect area. The BCP/CS membrane thus has the potential to be applied for guided bone regeneration.
關鍵字 Bone regeneration;Chitosan;Calcium phosphate
語言 en_US
ISSN
期刊性質 國外
收錄於 SCI SSCI
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/116951 )