Effect of Proton Pump Inhibitors on Mortality of Cirrhotic Patients with Pneumonia
學年 107
學期 2
出版（發表）日期 2019-04-25
作品名稱 Effect of Proton Pump Inhibitors on Mortality of Cirrhotic Patients with Pneumonia
作品名稱（其他語言）
著者 Tsung-Hsing Hung; Chih -Wei Tseng; Chih-Chun Tsai; Hsing-Feng Lee
單位
出版者
著錄名稱、卷期、頁數 PLoS One 14(4), e0216041
摘要 Objective Pneumonia is life-threatening in patients with liver cirrhosis. Proton pump inhibitors (PPIs) may increase the risk of these patients developing pneumonia. However, whether PPIs increase mortality in patients with cirrhosis and pneumonia remain unknown. Methods We used the Taiwan National Health Insurance Database to enroll 1,201 cirrhotic patients with pneumonia without active gastrointestinal bleeding who were receiving PPIs and were hospitalized between January 1, 2010 and December 31, 2013. A one-to-three propensity score match was performed to select a comparison group based on age, gender, and comorbid disorders. Results The overall 30-day and 90-day all-cause mortality rates were 13.7% and 26.9% in the PPI group, and 14.3% and 25.1% in the non-PPI group, respectively. After Cox regression model adjusting for age, gender, and comorbid disorders, the hazard ratios of the effect of PPIs on 30-day and 30 to 90-day mortality were 0.94 (95% Confidence Interval [CI], 0.79– 1.12, P = 0.468) and 1.26 (95% CI, 1.05–1.52; P = 0.013), respectively. Conclusions PPIs were not associated with 30-day mortality among cirrhotic patients with pneumonia but not active gastrointestinal bleeding. However, prolonged PPI therapy may be associated with higher mortality.
關鍵字
語言 en
ISSN 1932-6203
期刊性質 國外
收錄於 SCI
產學合作
通訊作者
審稿制度 否
國別 USA
公開徵稿
出版型式 ,電子版
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/118637 )

SDGS 良好健康和福祉