教師資料查詢 | 類別: 期刊論文 | 教師: 張玉坤 Yue-cune Chang (瀏覽個人網頁)

標題:Cartilage MRI T2* relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease
學年
學期
出版(發表)日期2017/06/21
作品名稱Cartilage MRI T2* relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease
作品名稱(其他語言)
著者Wang, Chao-Ying; Peng, Yi-Jen; Hsu, Yu-Juei; Lee, Herng-Sheng; Chang, Yue-Cune; Chang, C.-S.; Chiang, Shih-Wei; Hsu, Yi-Chih; Lin, Ming-Huang; Huang, Guo-Shu
單位
出版者
著錄名稱、卷期、頁數Osteoarthritis and Cartilage 25(6), p.976-985
摘要Objective
Chronic kidney disease (CKD) is characterized by metabolic disturbances in calcium and phosphorus homeostasis as kidney function declines. Alterations in blood perfusion in bone resulting from arteriosclerosis of bone vessels may relate to the progression of CKD. Herein, change in dynamic contrast enhanced (DCE) MRI parameters (A: amplitude, kel: elimination constant, and kep: permeability rate constant) and MRI T2∗ relaxation time of the knee cartilage were measured in a rodent nephrectomy model in order to (1) examine the relationship of peripheral blood perfusion to CKD and (2) demonstrate the feasibility of using DCE-MRI parameters and MRI T2∗ as imaging biomarkers to monitor disease progression.

Design
Two groups of male Sprague–Dawley rats received either (1) no intervention or (2) 5/6 nephrectomy.

Results
We found that the CKD group (compared with the control group) had lower A and kel values and similar kep value in the lateral and medial articular cartilages beginning at 12 weeks (P < 0.05); statistically significantly higher T2∗ values in the lateral and medial articular cartilages beginning at 18 weeks (P < 0.05); statistically significantly decreased inner luminal diameter of the popliteal artery, and altered structure of the lateral and medial articular cartilages (P < 0.05).

Conclusion
Perfusion deficiency and CKD may be related. DCE parameters and MRI T2∗ could serve as imaging biomarkers of cartilage degeneration in CKD progression.
關鍵字Chronic kidney disease;Dynamic contrast enhanced MRI;MRI T2∗ relaxation time;5/6 Nephrectomy;Cartilage;Knee
語言英文
ISSN1063-4584
期刊性質國外
收錄於SCI;
產學合作
通訊作者
審稿制度
國別英國
公開徵稿
出版型式,電子版,紙本
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