Conversion of shrimp heads to α-glucosidase inhibitors via co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041
學年 107
學期 1
出版（發表）日期 2018-08-01
作品名稱 Conversion of shrimp heads to α-glucosidase inhibitors via co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041
作品名稱（其他語言）
著者 Hsu C.H.; Nguyen V.B.; Nguyen A.D.; Wang San-Lang
單位
出版者
著錄名稱、卷期、頁數 Research on Chemical Intermediates 44(8), p.4597–4607
摘要 Alpha-glucosidase inhibitors (aGIs) have potential use as antidiabetic drugs for the treatment of type II diabetes. Most aGIs place a burden on the liver and cause gastrointestinal distress, therefore the development of new aGIs has become very important. In this study, we investigated the production of aGIs by the co-culture of Bacillus mycoides TKU040 and Rhizobium sp. TKU041 using shrimp head powder (SHP) as the sole source of carbon and nitrogen. After fermentation in 50 mL of 1% SHP-containing medium (0.1% K2HPO4 and 0.05% MgSO4·7H2O, pH 9.2) at 37 °C for 4 days, the maximum productivity of aGIs (143 U/mL) was reached. The IC50 of the aGIs produced in the culture supernatant was 3 mg/mL. The aGI activity was only 60% after treatment at pH 3 for 30 min; this increased to 140% after treatment at pH 11 for 30 min. The aGI activity remained at 60% after treatment at 60 °C for 30 min.
關鍵字 diabetes;glucosidase inhibitors;Bacillus;Rhizobium
語言 en
ISSN 0922-6168;1568-5675
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Wang San-Lang
審稿制度 是
國別 USA
公開徵稿
出版型式 ,電子版
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機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/110173 )

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