Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
學年 104
學期 2
出版（發表）日期 2016-02-01
作品名稱 Amphiphilic nanoparticles of resveratrol-norcantharidin to enhance the toxicity in zebrafish embryo
作品名稱（其他語言）
著者 Yan, De-Yue; Ni, Lin-Kai; Chen, Ho-Lun; Chen, Li-Chou; Chen, Yau-Hung; Cheng, Chien-Chung
單位
出版者
著錄名稱、卷期、頁數 Bioorganic & Medicinal Chemistry Letters 26(3), pp.774-777
摘要 Direct coupling of a hydrophobic drug and a hydrophilic natural product via an ester bond produced an amphiphilic adduct that formed liposomes. Liposomes of resveratrol–norcantharidin adduct are capable of forming a tadpole-like nanoparticle and exhibited high toxicity in zebrafish embryos to give the better transportation and the effective concentration into cells. Using fluorescent chromophore showed the liposome in the stomach and intestinal villi rather than in the skin and muscle. This result may provide an insight into the mechanism of action of traditional Chinese medicines, which often contain a significant amount of flavonoids and polyphenol analogs.
關鍵字 Liposome;Resveratrol;Norcantharidin;Drug delivery;Tadpole structure
語言 en
ISSN 0960-894X
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Yan, De-Yue; Chen, Yau-Hung; Cheng, Chien-Chung
審稿制度 否
國別 GBR
公開徵稿
出版型式 ,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/107113 )