Preparation of asymmetric polyhydroxybutyrate/chitosan composite membrane for guided bone regeneration
學年 102
學期 1
發表日期 2013-11-17
作品名稱 Preparation of asymmetric polyhydroxybutyrate/chitosan composite membrane for guided bone regeneration
作品名稱（其他語言）
著者 Trong-Ming Don; Hung-Yin Tai; Liao-Ping Cheng; Wei Lien
作品所屬單位
出版者
會議名稱 The 13th Pacific Polymer Conference(PPC 2013)
會議地點 Kaohsiung, Taiwan
摘要 In this study, an asymmetric composite membrane composed of a porous chitosan layer and a dense polyhydroxybutyrate (PHB) layer was prepared, and its mechanical properties as well as cellular compatibility were evaluated. First, the PHB dense layer with a thickness of ca. 32 m was obtained by direct oven-drying. After being treated with plasma to produce free radicals on the surface and subsequently graft polymerized with poly(acrylic acid), the PHB was immersed in the CS solution where the CS chains could be chemically bonded to the PHB surface via carbodiimide activation. After lyophilization, an asymmetric PHB/CS composite membrane was obtained. Compared to the porous CS membrane, the composite membrane had higher tensile mechanical properties. In addition, the fibroblast cells (L929 and HGF) and human osteoblast cells (hFOB1.19) were cultured on both sides of the composite membrane. All the cells could proliferate very well indicating that both PHB and CS layers were cellular compatible. Yet, the PHB dense layer could prohibit the fibroblast cells to penetrate through the membrane. Thus, the asymmetric composite membrane can be use as a potential barrier membrane for guided bone regeneration in periodontal tissue engineering.
關鍵字
語言 en_US
收錄於
會議性質 國內
校內研討會地點 無
研討會時間 20131117~20131117
通訊作者 Trong-Ming Don
國別 TWN
公開徵稿
出版型式
出處 The 13th Pacific Polymer Conference Program book, Poster-S8-034, pp.107
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/107423 )