Fabrication of asymmetric membranes from polyhydroxybutyrate and biphasic calcium phosphate/chitosan for guided bone regeneration
學年 102
學期 2
出版（發表）日期 2014-03-16
作品名稱 Fabrication of asymmetric membranes from polyhydroxybutyrate and biphasic calcium phosphate/chitosan for guided bone regeneration
作品名稱（其他語言）
著者 Hung-Yin Tai; Earl Fu; Liao-Ping Cheng; Trong-Ming Don
單位
出版者
著錄名稱、卷期、頁數 Journal of polymer research 21, 421(11pages)
摘要 Chitosan (CS) is known for its biocompatibility, antibacterial function, and wound healing acceleration, while calcium phosphate (CP) can promote bone regeneration.However, to be useful as barrier membrane for guided bone regeneration (GBR) in periodontal treatments, the membranes must have suitable mechanical strength in addition to good barrier properties. Therefore, a dense polyhydroxybutyrate (PHB) layer was integrated with a porous biphasic calcium phosphate/chitosan (BCP/CS) layer to form an asymmetric PHB-BCP/CS membrane. Moreover, for enhancing the interfacial strength, the PHB layer was chemically bonded to the BCP/CS layer through plasma-induced grafting of poly(acrylic acid) on its surface and followed by amidation with CS via carbodiimide activation. The incorporation of the PHB layer greatly increased the initial modulus and ultimate tensile strength of the membrane up to 524 and 16.5 MPa, respectively. In addition, the human gingival fibroblast (HGF) cells could proliferate very well on the PHB layer of the membrane, yet they were prohibited from down-growing through the membrane. Also, the addition of BCP particles in the CS layer increased the proliferation of osteoblast cells. Thus, the asymmetric PHB-BCP/CS membrane has the potential to be used as a barrier membrane for GBR in periodontal tissue engineering
關鍵字 Chitosan;Polyhydroxybutyrate;Calcium phosphate;Asymmetric membrane;Guided bone regeneration
語言 en
ISSN 1022-9760;1572-8935
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 Liao-Ping Cheng
審稿制度 否
國別 NLD
公開徵稿
出版型式 ,電子版,紙本
相關連結

機構典藏連結 ( http://tkuir.lib.tku.edu.tw:8080/dspace/handle/987654321/106341 )