THE EFFECTS OF EXTENSIONAL STRESS ON RED BLOOD CELL HEMOLYSIS
學年 104
學期 1
出版（發表）日期 2015-10-01
作品名稱 THE EFFECTS OF EXTENSIONAL STRESS ON RED BLOOD CELL HEMOLYSIS
作品名稱（其他語言）
著者 Jen-Hong Yen; Sheng-Fu Chen; Ming-Kai Chern; Po-Chien Lu
單位
出版者
著錄名稱、卷期、頁數 Biomedical Engineering: Applications, Basis and Communications 27(5), pp.1550042(11 pages)
摘要 Arti¯cial prostheses create non-physiologic °ow conditions with stress forces that may induce blood cell damage, particularly hemolysis. Earlier computational °uid dynamics (CFD) prediction models based on a quanti¯ed power model showed signi¯cant discrepancies with actual hemolysis experiments. These models used the premise that shear stresses act as the primary force behind hemolysis. However, additional studies have suggested that extensional stresses play a more substantial role than previously thought and should be taken into account in hemolysis models. We compared extensional and shear stress °ow ¯elds within the contraction of a short capillary with sharp versus tapered entrances. The °ow ¯eld was calculated with CFD to determine stress values, and hemolysis experiments with porcine red blood cells were performed to correlate the e®ects of extensional and shear stress on hemolysis. Our results support extensional stress as the primary mechanical force involved in hemolysis, with a threshold value of 1000 Pa under exposure time less than 0.060 ms.
關鍵字 Hemolysis;Computational;Fluid dynamics;Extensional stress;Short capillary
語言 en
ISSN 1016-2372 ; 1793-7132
期刊性質 國外
收錄於 SCI EI
產學合作
通訊作者 Po-Chien Lu
審稿制度 否
國別 SGP
公開徵稿
出版型式 ,電子版,紙本
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