Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones
學年 103
學期 2
出版（發表）日期 2015-06-22
作品名稱 Cobalt-Catalyzed Dual Annulation of o-Halobenzaldimine with Alkyne: A Powerful Route toward Bioactive Indenoisoquinolinones
作品名稱（其他語言）
著者 謝仁傑
單位
出版者 Wiley
著錄名稱、卷期、頁數 Chemistry 21(26), p.9544–9549
摘要 A cobalt-catalyzed dual annulation reaction for the synthesis of variously substituted indenoisoquinolinones from 2-bromobenzaldehydes, amines, and methyl 2-(ethynyl)benzoates has been developed. This method could also be applied to the synthesis of an array of highly functionalized bioactive indenoisoquinolinones and their derivatives. A possible mechanism of the cobalt catalysis is proposed, involving imine formation from bromobenzaldehyde and the amine, followed by a series of oxidative addition, alkyne insertion, cyclization reactions, and carbon-carbon double-bond migration. The regioselective alkyne insertion plays an important role for the success of the second annulation.
關鍵字 azametallacycles;cobalt;indenes;isoquinoline;zinc
語言 en
ISSN 0972-8376
期刊性質 國外
收錄於 SCI
產學合作
通訊作者 謝仁傑
審稿制度 是
國別 DEU
公開徵稿
出版型式 ,電子版,紙本
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